<article dtd-version="1.1d3">
<front>
<journal-meta>...</journal-meta>
<article-meta>...
<volume>97</volume>
<issue>4</issue>
<fpage>1665</fpage>
<lpage>1670</lpage>
<history>...</history>
<permissions>
<copyright-statement>Copyright &#x00A9; 2000, The National Academy of
Sciences</copyright-statement>
</permissions>
<abstract>
<p>We describe a method for cloning nucleic acid molecules
onto the surfaces of 5-&#x03BC;m microbeads rather than in biological hosts. A
unique tag sequence is attached to each molecule, and the tagged library is
amplified. Unique tagging of the molecules is achieved by sampling a small
fraction (1&#x0025;) of a very large repertoire of tag sequences. The resulting
library is hybridized to microbeads that each carry &#x2248;10<sup>6</sup>
strands complementary to one of the tags. About 10<sup>5</sup> copies of each
molecule are collected on each microbead. Because such clones are segregated on
microbeads, they can be operated on simultaneously and then assayed separately.
To demonstrate the utility of this approach, we show how to label and extract
microbeads bearing clones differentially expressed between two libraries by
using a fluorescence-activated cell sorter (FACS). Because no prior information
about the cloned molecules is required, this process is obviously useful where
sequence databases are incomplete or nonexistent. More importantly, the process
also permits the isolation of clones that are expressed only in given tissues or
that are differentially expressed between normal and diseased states. Such
clones then may be spotted on much more cost-effective, tissue- or
disease-directed, low-density planar microarrays.</p></abstract>
<kwd-group kwd-group-type="author">...</kwd-group>
</article-meta>
</front>
...</article>

   

<article dtd-version="1.1d3">
<front>
<article-meta>...
<permissions>
<copyright-statement>Copyright &#x00A9; 1999, British
Medical Journal</copyright-statement>
<copyright-year>1999</copyright-year>
</permissions>
<abstract abstract-type="section">
<sec>
<title>Objective</title>
<p>To examine the effectiveness of
day hospital attendance in prolonging independent living for elderly
people.</p>
</sec>
<sec>
<title>Design</title>
<p>Systematic review of 12 controlled clinical trials (available
by January 1997) comparing day hospital care with
comprehensive care (five trials), domiciliary care (four trials),
or no comprehensive care (three trials).</p>
</sec>
<sec>
<title>Subjects</title>
<p>2867 elderly people.</p>
</sec>
<sec>
<title>Main outcome measures</title>
<p>Death, institutionalisation, disability, global &#x201C;poor
outcome,&#x201D; and use of resources.</p>
</sec>
<sec>
<title>Results</title>
<p>Overall, there was no significant difference between day hospitals and
alternative services ...</p>
</sec>
<sec>
<title>Conclusions</title>
<p>Day hospital care seems to be an effective service for elderly
people ...</p>
<p><boxed-text position="float">
<sec>
<title>Key messages</title>
<p>...</p>
</sec>
</boxed-text></p>
</sec>
</abstract>
</article-meta>
</front>
...</article>

   

    ...
<article-meta>...  
<abstract>
<p>This is the third and last part of the volume devoted to solubility data of rare 
earth metal chlorides in water and in ternary and quaternary aqueous systems. 
Compilations of all available experimental data for each rare earth metal chloride 
are introduced with a corresponding critical evaluation. Every such evaluation 
contains a tabulated collection of all solubility results in water, a scheme of the 
water-rich part of the equilibrium ... Because the ternary and quaternary systems 
were almost never studied more than once, no critical evaluations or systematic 
comparisons of such data were possible. Simple chlorides (no complexes) of 
Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu are treated as the input substances. The 
literature (including a thorough coverage of papers in Chinese and Russian) 
has been covered through the middle of 2008.</p>
</abstract>
<abstract abstract-type="short">
<p>The is the third and last part of the volume devoted to solubility data of rare 
earth metal chlorides in water and in ternary and quaternary aqueous systems. 
Compilations of all available experimental data are introduced for each rare earth 
metal chloride with a corresponding critical evaluation. This part covers chlorides 
of Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu, with coverage of the literature through the 
middle of 2008.</p>
</abstract>
</article-meta>
...